Adaptive behavior assessed by Vineland-3 as comprehensive outcome measure in vanishing white matter.

ABSTRACT:

Objectives

Investigate the results and usability of the Vineland-3 as an outcome measure in vanishing white matter patients.

Methods

A cross-sectional investigation of the Vineland-3 based on interviews with caregivers, the Health Utilities Index, and the modified Rankin Scale in 64 vanishing white matter patients.

Results

Adaptive behavior measured with the Vineland-3 is impaired in the vast majority of vanishing white matter patients and significantly impacts daily life. Typically, the daily living skills domain is most severely affected and the socialization domain is the least affected. Based on the metric properties and the clinical relevance, the standard scores for the daily living skills domain and Adaptive Behavior Composite have the best properties to be use

SUBMITTER: Schoenmakers DH 

PROVIDER: S-EPMC10963295 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature