Predicting disability and mortality in CV2/CRMP5-IgG associated paraneoplastic neurologic disorders.

ABSTRACT:

Background

We aimed to investigate the prognostic factors associated with clinical outcomes in CV2/Collapsin response-mediator protein 5 (CRMP5)-IgG paraneoplastic neurologic disorders (PND).

Methods

This is a retrospective study of patients with CV2/CRMP5-IgG PND evaluated between 2002-2022. We examined the association of clinical variables (including age, clinical phenotype [autoimmune encephalopathy, myelopathy, polyneuropathy/radiculopathy, MG, cerebellar ataxia, chorea, optic neuropathy], cancer) with three clinical outcomes (wheelchair dependence, modified Rankin Scale [mRS], mortality) using univariate logistic regression and Cox proportional hazards modeling. Kaplan-Meier estimates were used to determine the probability of survival.

Results

Twenty-seven patien

SUBMITTER: Uysal SP 

PROVIDER: S-EPMC10963297 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature