Locked-in syndrome after central pontine myelinolysis, an outstanding outcome of two patients.

ABSTRACT:

Objective

Central pontine myelinolysis (CPM) is a rare demyelinating disease that affects the pons and which can cause extreme disabilities such as locked-in syndrome (LIS) in the initial phase. The aim of the study was to describe the evolution over a 12-month period of two patients with CPM causing an initial LIS.

Method

We retrospectively report the unexpected clinical outcome of these two patients in relation with the anatomical damages documented by brain MRI, associated with diffusion tensor imaging and reconstruction of corticospinal tracts in tractography. The following clinical parameters systematically assessed at 3, 6, 9, and 12 months: muscle testing on 12 key muscles (Medical Research Council), prehension metrics (box and block test and purdue pegboard), and ind

SUBMITTER: Chabert M 

PROVIDER: S-EPMC10963307 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature