Increased lesion detectability in patients with locally advanced breast cancer-A pilot study using dynamic whole-body [¹⁸F]FDG PET/CT.

ABSTRACT:

Background

Accurate diagnosis of axillary lymph node (ALN) metastases is essential for prognosis and treatment planning in breast cancer. Evaluation of ALN is done by ultrasound, which is limited by inter-operator variability, and by sentinel lymph node biopsy and/or ALN dissection, none of which are without risks and/or long-term complications. It is known that conventional 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) positron emission tomography/computed tomography (PET/CT) has limited sensitivity for ALN metastases. However, a recently developed dynamic whole-body (D-WB) [¹⁸F]FDG PET/CT scanning protocol, allowing for imaging of tissue [¹⁸F]FDG metabolic rate (MR_FDG), has been shown to have the potential to increase lesion det

SUBMITTER: Pedersen MA 

PROVIDER: S-EPMC10963357 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature