LRRC59 promotes the progression of oral squamous cell carcinoma by interacting with SRP pathway components and enhancing the secretion of CKAP4-containing exosomes.

ABSTRACT:

Background

As a ribosome receptor, LRRC59 was thought to regulate mRNA translation on the ER membrane. Evidence suggests that LRRC59 is overexpressed in a number of human malignancies and is associated with poor prognoses, but its primary biological function in the development of oral squamous cell carcinoma (OSCC) remains obscure.

Objective

The purpose of this study is to investigate at the expression changes and functional role of LRRC59 in OSCC.

Methods

LRRC59 gene expression and correlation with prognosis of OSCC patients were first examined using the data from The Cancer Genome Atlas (TCGA) databases. Following that, a series of functional experiments, including cell counting kit-8, cell cycle analysis, wound healing assays, and transwell assays, were carried out

SUBMITTER: Sun Q 

PROVIDER: S-EPMC10963372 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature