Alteration in gut microbiota is associated with immune imbalance in Graves' disease.

ABSTRACT:

Background

Graves' disease (GD), characterized by immune aberration, is associated with gut dysbiosis. Despite the growing interest, substantial evidence detailing the precise impact of gut microbiota on GD's autoimmune processes remains exceedingly rare.

Objective

This study was designed to investigate the influence of gut microbiota on immune dysregulation in GD.

Methods

It encompassed 52 GD patients and 45 healthy controls (HCs), employing flow cytometry and enzyme-linked immunosorbent assay to examine lymphocyte and cytokine profiles, alongside lipopolysaccharide (LPS) levels. Gut microbiota profiles and metabolic features were assessed using 16S rRNA gene sequencing and targeted metabolomics.

Results

Our observations revealed a disturbed B-cell distributio

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10963416 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature