Alteration of serum bile acid profiles of HBV-related hepatocellular carcinoma identified by LC-MS/MS.

ABSTRACT:

Background

Hepatocellular carcinoma closely related to metabolic disorders is a common and aggressive liver malignancy. The dysregulation of bile acid homeostasis has emerged as a key factor for the development and progression of HCC. We aimed to investigate the relationship between bile acids and HCC diagnosis and progression.

Methods

A total of 744 HBV-related patients (including 396 HCC patients and 348 patients with chronic liver diseases) were enrolled in the current study. The baseline characteristics of patients were collected from electronic medical records, and the levels of bile acid profiles were determined by LC-MS/MS. Propensity score matching analysis was conducted to reduce the effect of selection bias, and receiver operating characteristic analysis was perfor

SUBMITTER: Dai S 

PROVIDER: S-EPMC10963458 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature