Growth and remodeling of the dissected membrane in an idealized dissected aorta model.

ABSTRACT: While transitioning from the acute to chronic phase, the wall of a dissected aorta often expands in diameter and adaptations in thickness and microstructure take place in the dissected membrane. Including the mechanisms, leading to these changes, in a computational model is expected to improve the accuracy of predictions of the long-term complications and optimal treatment timing of dissection patients. An idealized dissected wall was modeled to represent the elastin and collagen production and/or degradation imposed by stress- and inflammation-mediated growth and remodeling, using the homogenized constrained mixture theory. As no optimal growth and remodeling parameters have been defined for aortic dissections, a Latin hypercube sampling with 1000 parameter combinations was assessed for f

SUBMITTER: Gheysen L 

PROVIDER: S-EPMC10963465 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature