Causality between allergic diseases and kidney diseases: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Evidence from observational studies and clinical trials suggests that the allergic diseases (ADs) are associated with kidney diseases (KDs). However, the causal association between them remains to be determined. We used bidirectional two-sample Mendelian randomization (MR) analysis to evaluate the potential causality between them.

Methods

Mendelian randomization (MR) was performed using publicly available genome-wide association study (GWAS) summary datasets. Inverse variance weighted (IVW), weighted median, MR-Egger regression, simple mode, and weighted mode methods are used to evaluate the causality between ADs and KDs. Sensitivity and heterogeneity analyses were used to ensure the stability of the results.

Results

The MR results indicated that genetic su

SUBMITTER: Peng Z 

PROVIDER: S-EPMC10963543 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature