A novel, microfluidic high-throughput single-cell encapsulation of human bone marrow mesenchymal stromal cells.

ABSTRACT: The efficacy of stem-cell therapy depends on the ability of the transplanted cells to escape early immunological reactions and to be retained at the site of transplantation. The use of tissue engineering scaffolds or injectable biomaterials as carriers has been proposed, but they still present limitations linked to a reliable manufacturing process, surgical practice and clinical outcomes. Alginate microbeads are potential candidates for the encapsulation of mesenchymal stromal cells with the aim of providing a delivery carrier suitable for minimally-invasive and scaffold-free transplantation, tissue-adhesive properties and protection from the immune response. However, the formation of stable microbeads relies on the cross-linking of alginate with divalent calcium ions at concentrations tha

SUBMITTER: Rashidi N 

PROVIDER: S-EPMC10963554 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature