Cellular interactions in tumor microenvironment during breast cancer progression: new frontiers and implications for novel therapeutics.

ABSTRACT: The breast cancer tumor microenvironment (TME) is dynamic, with various immune and non-immune cells interacting to regulate tumor progression and anti-tumor immunity. It is now evident that the cells within the TME significantly contribute to breast cancer progression and resistance to various conventional and newly developed anti-tumor therapies. Both immune and non-immune cells in the TME play critical roles in tumor onset, uncontrolled proliferation, metastasis, immune evasion, and resistance to anti-tumor therapies. Consequently, molecular and cellular components of breast TME have emerged as promising therapeutic targets for developing novel treatments. The breast TME primarily comprises cancer cells, stromal cells, vasculature, and infiltrating immune cells. Currently, numerous clini

SUBMITTER: Akinsipe T 

PROVIDER: S-EPMC10963559 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature