DNA Methylation Signatures Correlate with Response to Immune Checkpoint Inhibitors in Metastatic Melanoma.

ABSTRACT:

Background

DNA methylation profiles have emerged as potential predictors of therapeutic response in various solid tumors.

Objective

This study aimed to analyze the DNA methylation profiles of patients with stage IV metastatic melanoma undergoing first-line immune checkpoint inhibitor treatment and evaluate their correlation with a radiological response according to immune-related Response Evaluation Criteria in Solid Tumors (iRECIST).

Methods

A total of 81 tissue samples from 71 patients with metastatic melanoma (27 female, 44 male) were included in this study. We utilized Illumina Methylation EPIC Beadchips to retrieve their genome-wide methylation profile by interrogating >850,000 CpG sites. Clustering based on the 500 most differentially methylated genes was conduc

SUBMITTER: Ressler JM 

PROVIDER: S-EPMC10963567 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature