Multiscale mechanical characterisation of the craniofacial system under external forces.

ABSTRACT: Premature fusion of craniofacial joints, i.e. sutures, is a major clinical condition. This condition affects children and often requires numerous invasive surgeries to correct. Minimally invasive external loading of the skull has shown some success in achieving therapeutic effects in a mouse model of this condition, promising a new non-invasive treatment approach. However, our fundamental understanding of the level of deformation that such loading has induced across the sutures, leading to the effects observed is severely limited, yet crucial for its scalability. We carried out a series of multiscale characterisations of the loading effects on normal and craniosynostotic mice, in a series of in vivo and ex vivo studies. This involved developing a custom loading setup as well as software fo

SUBMITTER: Didziokas M 

PROVIDER: S-EPMC10963580 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature