Factors associated with vertical transmission of HIV in the Western Cape, South Africa: a retrospective cohort analysis.

ABSTRACT:

Introduction

Monitoring mother-infant pairs with HIV exposure is needed to assess the effectiveness of vertical transmission (VT) prevention programmes and progress towards VT elimination.

Methods

We used routinely collected data on infants with HIV exposure, born May 2018-April 2021 in the Western Cape, South Africa, with follow-up through mid-2022. We assessed the proportion of infants diagnosed with HIV at birth (≤7 days), 10 weeks (>1 to 14 weeks) and >14 weeks as proxies for intrauterine, intrapartum/early breastfeeding and late breastfeeding transmission, respectively. We used mixed-effects Poisson regression to assess factors associated with VT in mothers known with HIV by delivery.

Results

We included 50,461 infants born to mothers known with HIV by delivery.

SUBMITTER: Anderson K 

PROVIDER: S-EPMC10963590 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature