Prognostic correlation between specialized capillary endothelial cells and lung adenocarcinoma.

ABSTRACT:

Background

In-depth analysis of the functional changes occurring in endothelial cells (ECs) involved in capillary formation can help to elucidate the mechanism of tumour vascular growth.

Methods

Appropriate datasets were retrieved from the GEO database to obtain single-cell data on LUAD samples and adjacent normal tissue samples. ECs were selected by an automatic annotation program in R and further subdivided based on reported EC marker genes. Functional changes in different types of capillary ECs were then visualized, and the concrete expression was classified by genetic data in the TCGA. Finally, a prognostic model was constructed to predict immunoinfiltration status, survival and drug therapy effects.

Results

The LUAD data contained in the GSE183219 dataset were su

SUBMITTER: Zhao R 

PROVIDER: S-EPMC10963648 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature