Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers.

ABSTRACT: For many cancers there are only a few well-established risk factors. Here, we use summary data from genome-wide association studies (GWAS) in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to identify potentially causal relationships for over 3,000 traits. Our outcome datasets comprise 378,142 cases across breast, prostate, colorectal, lung, endometrial, oesophageal, renal, and ovarian cancers, as well as 485,715 controls. We complement this analysis by systematically mining the literature space for supporting evidence. In addition to providing supporting evidence for well-established risk factors (smoking, alcohol, obesity, lack of physical activity), we also find sex steroid hormones, plasma lipids, and telomere length as determinants of cancer risk. A number of t

SUBMITTER: Went M 

PROVIDER: S-EPMC10963765 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature