Gene expression reprogramming of Pseudomonas alloputida in response to arginine through the transcriptional regulator ArgR.

ABSTRACT: Different bacteria change their life styles in response to specific amino acids. In Pseudomonas putida (now alloputida) KT2440, arginine acts both as an environmental and a metabolic indicator that modulates the turnover of the intracellular second messenger c-di-GMP, and expression of biofilm-related genes. The transcriptional regulator ArgR, belonging to the AraC/XylS family, is key for the physiological reprogramming in response to arginine, as it controls transport and metabolism of the amino acid. To further expand our knowledge on the roles of ArgR, a global transcriptomic analysis of KT2440 and a null argR mutant growing in the presence of arginine was carried out. Results indicate that this transcriptional regulator influences a variety of cellular functions be

SUBMITTER: Molina-Henares MA 

PROVIDER: S-EPMC10963909 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature