Morphometric similarity differences in drug-naive Parkinson's disease correlate with transcriptomic signatures.

ABSTRACT:

Background

Differences in cortical morphology have been reported in individuals with Parkinson's disease (PD). However, the pathophysiological mechanism of transcriptomic vulnerability in local brain regions remains unclear.

Objective

This study aimed to characterize the morphometric changes of brain regions in early drug-naive PD patients and uncover the brain-wide gene expression correlates.

Methods

The morphometric similarity (MS) network analysis was used to quantify the interregional structural similarity from multiple magnetic resonance imaging anatomical indices measured in each brain region of 170 early drug-naive PD patients and 123 controls. Then, we applied partial least squares regression to determine the relationship between regional changes in MS and spa

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10964038 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature