Etiological Spectrum of Cirrhosis in India: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Cirrhosis is a significant cause of morbidity and mortality globally and in India. This systematic review and meta-analysis aimed to ascertain the etiological spectrum and changing trends of cirrhosis in India.

Methods

We searched electronic databases, including Pubmed/Medline, Scopus, and Embase. We included original studies that reported the etiology of cirrhosis in the Indian population.

Results

We included 158 studies (adults: 147, children: 11). The overall pooled estimate of alcohol as a cause of cirrhosis in adults was 43.2% (95% confidence interval (CI) 39.8-46.6%; I² = 97.8%), followed by nonalcoholic fatty liver disease (NAFLD)/cryptogenic in 14.4%, 95% CI (11.7-17.3%; I² = 98.4%), hepatitis B virus (HBV) in 11.5%, 95% CI (9.

SUBMITTER: Swaroop S 

PROVIDER: S-EPMC10964076 | biostudies-literature | 2024 Mar-Apr

REPOSITORIES: biostudies-literature