Investigation of Anti-inflammatory, Antipyretic and Analgesic Activities of Citrullus colocynthis in Albino Rats through in vivo and Pharmacoinformatics Studies.

ABSTRACT:

Introduction

Hyperpyrexia, algesia and inflammation are pathological disorders which are treated with synthetic as well as herbal medications.

Aims

The basic aim of the present study is to evaluate the ethnopharmacological activities of phytoconstituents that are present in C. colocynthis (fruit extract) by using in vivo and in silico studies.

Methods

Thirty-six albino rats were used in our studies with an average weight between 150-170 g. Anti-inflammatory activity was investigated using carrageenan (an extract from a red seaweed) that induced edema in albino rat paws. However, in antipyretic and analgesic activity studies, yeast and acetic acid were used to cause pyrexia or algesia, respectively. Different doses of acetone fruit extract were used to tr

SUBMITTER: Hassan M 

PROVIDER: S-EPMC10964079 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature