Rhodium(I)-Catalyzed Defluorinative Bisarylation of Monofluorodienes with Boronic Acids.

ABSTRACT: We herein describe a Rh(I)-catalyzed bisarylation reaction of monofluorodienes using arylboronic acids. Two aryl groups are installed in the trisubstituted (E)-alkene products in one step with excellent diastereoselectivities. An intriguing reaction sequence of Rh(I)-catalyzed 1,6-addition followed by defluorinative coupling is proposed for product formation.

SUBMITTER: Li M 

PROVIDER: S-EPMC10964235 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature