Decrease of 5-hydroxymethylcytosine in primary cutaneous CD4⁺ small/medium sized pleomorphic T-cell lymphoproliferative disorder.

ABSTRACT:

Background

Primary cutaneous CD4⁺ small/medium-sized pleomorphic T-Cell lymphoproliferative disorder (PC-SMTLD) has been considered as a controversial dermatological disease that has been included in cutaneous T-cell lymphoma group, presenting most commonly as a solitary nodule and/or plaque with a specific and characteristic head and neck predilection. Due to the considerable overlap between PC-SMTLD and pseudolymphoma (PL), the differential diagnosis is often challenging. Methylation of DNA at position 5 of cytosine, and the subsequent reduction in intracellular 5-hydroxymethylcytosine (5-hmC) levels, is a key epigenetic event in several cancers, including systemic lymphomas. However, it has rarely been studied in cutaneous lymphomas.

Objectives

The authors aime

SUBMITTER: Hu J 

PROVIDER: S-EPMC10964357 | biostudies-literature | 2024 Jan-Feb

REPOSITORIES: biostudies-literature