Manganese homeostasis modulates fungal virulence and stress tolerance in Candida albicans.

ABSTRACT: Due to the scarcity of transition metals within the human host, fungal pathogens have evolved sophisticated mechanisms to uptake and utilize these micronutrients at the infection interface. While considerable attention was turned to iron and copper acquisition mechanisms and their importance in fungal fitness, less was done regarding either the role of manganese (Mn) in infectious processes or the cellular mechanism by which fungal cells achieve their Mn-homeostasis. Here, we undertook transcriptional profiling in the pathogenic fungus Candida albicans experiencing both Mn starvation and excess to capture biological processes that are modulated by this metal. We uncovered that Mn scarcity influences diverse processes associated with fungal fitness including invasion of host cells an

SUBMITTER: Henry M 

PROVIDER: S-EPMC10964418 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature