Menarche, pubertal timing and the brain: female-specific patterns of brain maturation beyond age-related development.

ABSTRACT:

Background

Puberty depicts a period of profound and multifactorial changes ranging from social to biological factors. While brain development in youths has been studied mostly from an age perspective, recent evidence suggests that pubertal measures may be more sensitive to study adolescent neurodevelopment, however, studies on pubertal timing in relation to brain development are still scarce.

Methods

We investigated if pre- vs. post-menarche status can be classified using machine learning on cortical and subcortical structural magnetic resonance imaging (MRI) data from strictly age-matched adolescent females from the Adolescent Brain Cognitive Development (ABCD) cohort. For comparison of the identified menarche-related patterns to age-related patterns of neurodevelopment, we

SUBMITTER: Gottschewsky N 

PROVIDER: S-EPMC10964568 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature