Phenome-wide causal associations between osteoarthritis and other complex traits through the latent causal variable analysis.

ABSTRACT:

Background

Individuals with osteoarthritis present with comorbidities, and the potential causal associations remain incompletely elucidated. The present study undertook a large-scale investigation about the causality between osteoarthritis and variable traits, using the summary-level data of genome-wide association studies (GWAS).

Methods

The present study included the summary-level GWS data of knee osteoarthritis, hip osteoarthritis, hip or knee osteoarthritis, hand osteoarthritis, and other 1355 traits. Genetic correlation analysis was conducted between osteoarthritis and other traits through cross-trait bivariate linkage disequilibrium score regression. Subsequently, latent causal variable analysis was performed to explore the causal association when there was a significa

SUBMITTER: Mei L 

PROVIDER: S-EPMC10964580 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature