The upregulation of VGF enhances the progression of oral squamous carcinoma.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) is a prevalent neoplasm worldwide, necessitating a deeper understanding of its pathogenesis. VGF nerve growth factor inducible (VGF), a neuropeptide, plays critical roles in nerve and endocrine cell regulation.

Methods

In this study, the TCGA datasets were initially screened, identifying the upregulation of VGF in various malignancies. We focused on OSCC cell lines, identifying the suppressor mRNA miR-432-5p as a negative regulator of VGF. Additionally, we examined the prognostic value of VGF expression in OSCC tumors and its impact on cellular functions.

Results

VGF expression was found to be an independent prognostic predictor in OSCC tumors. Cells expressing VGF exhibited increased oncogenicity, influencing the prolife

SUBMITTER: Chou CH 

PROVIDER: S-EPMC10964619 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature