Derivation and external validation of a simple risk score for predicting severe acute kidney injury after intravenous cisplatin: cohort study.

ABSTRACT:

Objective

To develop and externally validate a prediction model for severe cisplatin associated acute kidney injury (CP-AKI).

Design

Multicenter cohort study.

Setting

Six geographically diverse major academic cancer centers across the US.

Participants

Adults (≥18 years) receiving their first dose of intravenous cisplatin, 2006-22.

Main outcome measures

The primary outcome was CP-AKI, defined as a twofold or greater increase in serum creatinine or kidney replacement therapy within 14 days of a first dose of intravenous cisplatin. Independent predictors of CP-AKI were identified using a multivariable logistic regression model, which was developed in a derivation cohort and tested in an external validation cohort. For the primary model, continuous variables

SUBMITTER: Gupta S 

PROVIDER: S-EPMC10964715 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature