Can TERT rs2853669 polymorphysm indicate fibrosis in sarcoidosis?

ABSTRACT:

Background and aim

Sarcoidosis is a systemic inflammatory disease of unknown cause, characterized by the presence of non-caseating granulomas, which can affect all organs in the body, especially the lung. The fibrotic stage 4 of sarcoidosis usually does not respond adequately to treatment and may cause respiratory distress in the patient. Some telomerase gene polymorphisms have been significantly associated with lung cancer and idiopathic pulmonary fibrosis. In our study, we aimed to investigate the relationship between telomerase mutation and progression to fibrosis in patients with sarcoidosis.

Methods

A total of 93 patients, including 18 males and 73 females, who were clinically and histopathologically diagnosed with sarcoidosis were included in the study. The 78 patients

SUBMITTER: Kement S 

PROVIDER: S-EPMC10965005 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature