Non-coding 886 (nc886/vtRNA2-1), the epigenetic odd duck - implications for future studies.

ABSTRACT: Non-coding 886 (nc886, vtRNA2-1) is the only human polymorphically imprinted gene, in which the methylation status is not determined by genetics. Existing literature regarding the establishment, stability and consequences of the methylation pattern, as well as the nature and function of the nc886 RNAs transcribed from the locus, are contradictory. For example, the methylation status of the locus has been reported to be stable through life and across somatic tissues, but also susceptible to environmental effects. The nature of the produced nc886 RNA(s) has been redefined multiple times, and in carcinogenesis, these RNAs have been reported to have conflicting roles. In addition, due to the bimodal methylation pattern of the nc886 locus, traditional genome-w

SUBMITTER: Raitoharju E 

PROVIDER: S-EPMC10965113 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature