Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia.

ABSTRACT: Excessive immune activation contributes to the onset of early dysfunction of the maternal-fetal interface, and it is closely linked to the development of pre-eclampsia. However, the effect of specific immune cells on the risk of pre-eclampsia and eclampsia remains controversial. We investigated the causal relationship between immune cells and pre-eclampsia and eclampsia. For exposure, we extracted genetic variants associated with immune cell-related traits, and for outcomes, we used summary genetic data of pre-eclampsia/eclampsia. A two-sample Mendelian randomization (MR) analysis was then performed to assess the causal relationship. Robustness of the MR results was then evaluated through colocalization analysis. We found that genetically proxied circulating lymphocyte absolute count was c

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC10965280 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature