Mitigation of Osteoclast-Mediated Arthritic Bone Remodeling By Short Chain Fatty Acids.

ABSTRACT:

Objective

The objective for this study was to evaluate the effects of short chain fatty acids (SCFAs) on arthritic bone remodeling.

Methods

We treated a recently described preclinical murine model of psoriatic arthritis (PsA), R26STAT3C^stopfl/fl CD4Cre mice, with SCFA-supplemented water. We also performed in vitro osteoclast differentiation assays in the presence of serum-level SCFAs to evaluate the direct impact of these microbial metabolites on maturation and function of osteoclasts. We further characterized the molecular mechanism of SCFAs by transcriptional analysis.

Results

The osteoporosis condition in R26STAT3C^stopfl/fl CD4Cre animals is attributed primarily to robust osteoclast differentiation driven by an expansion of osteoclast progenit

SUBMITTER: Yang KL 

PROVIDER: S-EPMC10965381 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature