An integrative pan-cancer analysis of the molecular characteristics of dietary restriction in tumour microenvironment.

ABSTRACT:

Background

Dietary restriction (DR), a general term for dieting, has been demonstrated as an effective intervention in reducing the occurrence of cancers. Molecular activities associated with DR are crucial in mediating its anti-cancer effects, yet a comprehensive exploration of the landscape of these activities at the pan-cancer level is still lacking.

Methods

We proposed a computational approach for quantifying DR-related molecular activities and delineating the landscape of these activities across 33 cancer types and 30 normal tissues within 27,320 samples. We thoroughly examined the associations between DR-related molecular activities and various factors, including the tumour microenvironment, immunological phenotypes, genomic features, and clinical prognosis. Meanwhile,

SUBMITTER: Song X 

PROVIDER: S-EPMC10965464 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature