Structural connectivity of low-frequency subthalamic stimulation for improving stride length in Parkinson's disease.

ABSTRACT:

Background

A reduction in stride length is considered a key characteristic of gait kinematics in Parkinson's disease (PD) and has been identified as a predictor of falls. Although low-frequency stimulation (LFS) has been suggested as a method to improve gait characteristics, the underlying structural network is not well understood.

Objective

This study aims to investigate the structural correlates of changes in stride length during LFS (85 Hz).

Methods

Objective gait performance was retrospectively evaluated in 19 PD patients who underwent deep brain stimulation (DBS) at 85 Hz and 130 Hz. Individual DBS contacts and volumes of activated tissue (VAT) were computed using preoperative magnetic resonance imaging (MRI) and postoperative computed tomography (CT) scans. Stru

SUBMITTER: Calvano A 

PROVIDER: S-EPMC10965492 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature