Potential of Ilheus virus to emerge.

ABSTRACT: Ilhéus virus (ILHV)(Flaviviridae:Orthoflavivirus) is an arthropod-borne virus (arbovirus) endemic to Central and South America and the Caribbean. First isolated in 1944, most of our knowledge derives from surveillance and seroprevalence studies. These efforts have detected ILHV in a broad range of mosquito and vertebrate species, including humans, but laboratory investigations of pathogenesis and vector competence have been lacking. Here, we develop an immune intact murine model with several ages and routes of administration. Our model closely recapitulates human neuroinvasive disease with ILHV strain- and mouse age-specific virulence, as well as a uniformly lethal Ifnar^-/- A129 immunocompromised model. Replication kinetics in several vertebrate and invertebrate ce

SUBMITTER: Plante KS 

PROVIDER: S-EPMC10965525 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature