PCGIMA: developing the web server for human position-defined CpG islands methylation analysis.

ABSTRACT: Introduction: CpG island (CGI) methylation is one of the key epigenomic mechanisms for gene expression regulation and chromosomal integrity. However, classical CGI prediction methods are neither easy to locate those short and position-sensitive CGIs (CpG islets), nor investigate genetic and expression pattern for CGIs under different CpG position- and interval- sensitive parameters in a genome-wide perspective. Therefore, it is urgent for us to develop such a bioinformatic algorithm that not only can locate CpG islets, but also provide CGI methylation site annotation and functional analysis to investigate the regulatory mechanisms for CGI methylation. Methods: This study develops Human position-defined CGI prediction method to locate CpG islets using high performance computin

SUBMITTER: Xiao M 

PROVIDER: S-EPMC10965558 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature