Predicting the primary infection source of Escherichia coli bacteremia using virulence-associated genes.

ABSTRACT:

Purpose

To investigate the role of E. coli virulence-associated genes (VAGs) in predicting urinary tract infection (UTI) as the source of bacteremia in two distinct hospital populations, one with a large general catchment area and one dominated by referrals.

Methods

E. coli bacteremias identified at Department of Clinical Microbiology (DCM), Hvidovre Hospital and DCM, Rigshospitalet in the Capital Region of Denmark from October to December 2018. Using whole genome sequencing (WGS), we identified 358 VAGs from 224 E. coli bacteremia. For predictive analysis, VAGs were paired with clinical source of UTI from local bacteremia databases.

Results

VAGs strongly predicting of UTI as primary infection source of bacteremia were primarily found within the pap gene family. papX

SUBMITTER: Ilsby CS 

PROVIDER: S-EPMC10965582 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature