Stressful life events and depression and fatigue in people with multiple sclerosis: a cross-sectional analysis of an international cohort.

ABSTRACT:

Background

Relationships between stressful life events (SLEs) and health outcomes in people living with multiple sclerosis (plwMS), beyond relapse, are not well-established. We examined associations between SLEs and fatigue and symptoms of depression in plwMS.

Methods

948 participants were queried whether they had experienced any of the 16 SLEs (Holmes-Rahe Social Readjustment Rating Scale) in the preceding 12 months. SLEs were summated to estimate SLE number and SLE load (weighted for the degree of associated stress). Cross-sectional associations between SLE (number, load and individual) and fatigue, and depressive symptoms were examined using log-binomial or log-multinomial regression adjusted for age, sex, relapse symptoms, education, MS type at baseline, disability, fati

SUBMITTER: Reece JC 

PROVIDER: S-EPMC10965589 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature