Malignancy-associated ischemic stroke: Implications for diagnostic and therapeutic workup.
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ABSTRACT: Background
Patients with malignancies have an increased risk of suffering ischemic stroke via several mechanisms such as coagulation dysfunction and other malignancy-related effects as well as iatrogenic causes. Moreover, stroke can be the first sign of an occult malignancy, termed as malignancy-associated ischemic stroke (MAS). Therefore, timely diagnostic assessment and targeted management of this complex clinical situation are critical.Findings
Patients with both stroke and malignancy have atypical ages, risk factors, and often exhibit malignancy-related symptoms and multiple lesions on neuroimaging. New biomarkers such as eicosapentaenoic acid and blood mRNA profiles may help in distinguishing MAS from other strokes. In terms of treatment, malignancy should not be considered a contraindication, given comparable rates of recanalization and complications between stroke patients with or without malignancies.Conclusion
In this review, we summarize the latest developments in diagnosing and managing MAS, especially stroke with occult malignancies, and provide new recommendations from recently emerged clinical evidence for diagnostic and therapeutic workup strategies.
SUBMITTER: Xie W
PROVIDER: S-EPMC10965754 | biostudies-literature | 2024 Mar
REPOSITORIES: biostudies-literature
Publications
Malignancy-associated ischemic stroke: Implications for diagnostic and therapeutic workup.
Xie Wanqing W Hsu Szuyao S Lin Yuxuan Y Xie Lv L Jin Xia X Zhu Ziyu Z Guo Yunlu Y Chen Caiyang C Huang Dan D Boltze Johannes J Li Peiying P
CNS neuroscience & therapeutics 20240301 3
<h4>Background</h4>Patients with malignancies have an increased risk of suffering ischemic stroke via several mechanisms such as coagulation dysfunction and other malignancy-related effects as well as iatrogenic causes. Moreover, stroke can be the first sign of an occult malignancy, termed as malignancy-associated ischemic stroke (MAS). Therefore, timely diagnostic assessment and targeted management of this complex clinical situation are critical.<h4>Findings</h4>Patients with both stroke and ma ...[more]
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