Interleukin-16 is increased in obesity and alters adipogenesis and inflammation in vitro.

ABSTRACT:

Introduction

Obesity is a chronic condition associated with low-grade inflammation mainly due to immune cell infiltration of white adipose tissue (WAT). WAT is distributed into two main depots: subcutaneous WAT (sWAT) and visceral WAT (vWAT), each with different biochemical features and metabolic roles. Proinflammatory cytokines including interleukin (IL)-16 are secreted by both adipocytes and infiltrated immune cells to upregulate inflammation. IL-16 has been widely studied in the peripheral proinflammatory immune response; however, little is known about its role in adipocytes in the context of obesity.

Aim & methods

We aimed to study the levels of IL-16 in WAT derived from sWAT and vWAT depots of humans with obesity and the role of this cytokine in palmitate-exposed 3T3-L1

SUBMITTER: Reyes-Farias M 

PROVIDER: S-EPMC10965774 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature