Mapping the tRNA modification landscape of Bartonella henselae Houston I and Bartonella quintana Toulouse.

ABSTRACT: Transfer RNA (tRNA) modifications play a crucial role in maintaining translational fidelity and efficiency, and they may function as regulatory elements in stress response and virulence. Despite their pivotal roles, a comprehensive mapping of tRNA modifications and their associated synthesis genes is still limited, with a predominant focus on free-living bacteria. In this study, we employed a multidisciplinary approach, incorporating comparative genomics, mass spectrometry, and next-generation sequencing, to predict the set of tRNA modification genes responsible for tRNA maturation in two intracellular pathogens-Bartonella henselae Houston I and Bartonella quintana Toulouse, which are causative agents of cat-scratch disease and trench fever, respectively. This analysis presen

SUBMITTER: Quaiyum S 

PROVIDER: S-EPMC10965804 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature