Psilocybin enhances insightfulness in meditation: a perspective on the global topology of brain imaging during meditation.

ABSTRACT: In this study, for the first time, we explored a dataset of functional magnetic resonance images collected during focused attention and open monitoring meditation before and after a five-day psilocybin-assisted meditation retreat using a recently established approach, based on the Mapper algorithm from topological data analysis. After generating subject-specific maps for two groups (psilocybin vs. placebo, 18 subjects/group) of experienced meditators, organizational principles were uncovered using graph topological tools, including the optimal transport (OT) distance, a geometrically rich measure of similarity between brain activity patterns. This revealed characteristics of the topology (i.e. shape) in space (i.e. abstract space of voxels) and time dimension of whole-brain activity patter

SUBMITTER: Berit S 

PROVIDER: S-EPMC10966054 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature