The C-type lectin DCIR contributes to the immune response and pathogenesis of colorectal cancer.

ABSTRACT: Development and progression of malignancies are accompanied and influenced by alterations in the surrounding immune microenvironment. Understanding the cellular and molecular interactions between immune cells and cancer cells has not only provided important fundamental insights into the disease, but has also led to the development of new immunotherapies. The C-type lectin Dendritic Cell ImmunoReceptor (DCIR) is primarily expressed by myeloid cells and is an important regulator of immune homeostasis, as demonstrated in various autoimmune, infectious and inflammatory contexts. Yet, the impact of DCIR on cancer development remains largely unknown. Analysis of available transcriptomic data of colorectal cancer (CRC) patients revealed that high DCIR gene expression is associated with improved p

SUBMITTER: Trimaglio G 

PROVIDER: S-EPMC10966077 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature