Repeatability and reproducibility of prostate apparent diffusion coefficient values on a 1.5 T magnetic resonance linear accelerator.

ABSTRACT:

Background and purpose

Integrated magnetic resonance linear accelerator (MR-Linac) systems offer potential for biologically based adaptive radiation therapy using apparent diffusion coefficient (ADC). Accurate tracking of longitudinal ADC changes is key to establishing ADC-driven dose adaptation. Here, we report repeatability and reproducibility of intraprostatic ADC using deformable image registration (DIR) to correct for inter-fraction prostate changes.

Materials and methods

The study included within-fraction repeat ADC measurements for three consecutive fractions for 20 patients with prostate cancer treated on a 1.5 T MR-Linac. We deformably registered successive fraction T₂-weighted images and applied the deformation vector field to corresponding ADC maps to a

SUBMITTER: Fernando N 

PROVIDER: S-EPMC10966090 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature