Normobaric hyperoxia alleviates complement C3-mediated synaptic pruning and brain injury after intracerebral hemorrhage.

ABSTRACT:

Background

Intracerebral hemorrhage (ICH) is a common cerebrovascular disease, and the complement cascade exacerbates brain injury after ICH. As the most abundant component of the complement system, complement component 3 (C3) plays essential roles in all three complement pathways. However, the effects of C3 on neurological impairment and brain injury in ICH patients and the related mechanism have not been fully elucidated. Normobaric hyperoxia (NBO) is regarded as a treatment for ICH patients, and recent clinical studies also have confirmed the neuroprotective role of NBO against acute ICH-mediated brain damage, but the underlying mechanism still remains elusive.

Aims

In the present study, we investigated the effects of complement C3 on NBO-treated ICH patients and model mi

SUBMITTER: Wu M 

PROVIDER: S-EPMC10966135 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature