Fas ligand regulate nerve injury and repair by affecting AKT, β-catenin, and NF-κB pathways.

ABSTRACT:

Objective

To investigate the regulatory effect of Fas-L on the repair and regeneration of peripheral extension injury in rats.

Methods

This study aimed to explore the effects of Fas-L on apoptosis and axonal regeneration of dorsal root ganglion (DRG) cells in rat peripheral nerve repair and regeneration by using several relevant experimental techniques from the injured nerve animal model, cell biology, and molecular biology.

Results

The expression level of Fas-L in DRG tissues was significantly down-regulated after sciatic nerve injury. Interference with Fas-L can significantly promote the regeneration of DRG neuronal axons and inhibit apoptosis, while the overexpression of Fas-L is contrary to it. Moreover, Fas-L may play a role in the regulation of DRG function and

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC10966190 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature