Long-term outcomes and reverse remodelling in recently diagnosed unexplained left ventricular systolic dysfunction.

ABSTRACT:

Aims

In patients with recently diagnosed non-ischaemic LV systolic dysfunction, left ventricular reverse remodelling (LVRR) and favourable prognosis has been documented in studies with short-term follow-up. The aim of our study was to assess the long-term clinical course and stability of LVRR in these patients.

Methods and results

We prospectively studied 133 patients (37 women; 55 [interquartile range 46, 61] years) with recently diagnosed unexplained LV systolic dysfunction, with heart failure symptoms lasting <6 months and LV ejection fraction <40% persisting after at least 1 week of therapy. All patients underwent endomyocardial biopsy (EMB) at the time of diagnosis and serial echocardiographic and clinical follow-up over 5 years. LVRR was defined as the combined presenc

SUBMITTER: Kuchynka P 

PROVIDER: S-EPMC10966214 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature