Effects of salt and protein intake on polyuria in V2RA-treated ADPKD patients.

ABSTRACT:

Background

The only treatment proven to be renoprotective in autosomal dominant polycystic kidney disease (ADPKD) is a vasopressin V2-receptor antagonist (V2RA). However, aquaresis-associated side effects limit tolerability. We investigated whether salt and/or protein intake influences urine volume and related endpoints in V2RA-treated ADPKD patients.

Methods

In this randomized, controlled, double-blind, crossover trial, ADPKD patients treated with maximally tolerated dose of a V2RA were included. While on a low salt and low protein diet, patients were given additional salt and protein to mimic regular intake, which was subsequently replaced by placebo in random order during four 2-week periods. Primary endpoint was change in 24-h urine volume. Secondary endpoints were chang

SUBMITTER: Geertsema P 

PROVIDER: S-EPMC10966325 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature