Bone marrow niche chemoprotection of metastatic solid tumors mediated by CYP3A4.

ABSTRACT:

Background

The bone/bone marrow is one of the most common sites for metastatic solid tumors. Moreover, the tumor microenvironment is an essential part of cancer homeostasis. Previously, it was shown that cytochrome P450 enzymes (CYPs) are present in the bone marrow (BM) microenvironment, particularly in the mesenchymal stroma cells, at levels comparable to those of hepatocytes. It was found that the CYPs play important roles in nurturing and maintaining normal hematopoietic stem cells as well as multiple myeloma and leukemia cells, including protecting them from toxic insults. It was hypothesized that the CYPs in the BM microenvironment might play a similar role in solid tumors metastatic to bone.

Methods

The interaction between the BM microenvironment and malignant cells th

SUBMITTER: Ghiaur G 

PROVIDER: S-EPMC10966383 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature