Ultrasonographic Fetal Nuchal Translucency Measurements and Cytogenetic Outcomes.

ABSTRACT:

Importance

Ultrasonographic measurement of fetal nuchal translucency is used in prenatal screening for trisomies 21 and 18 and other conditions. A cutoff of 3.5 mm or greater is commonly used to offer follow-up investigations, such as prenatal cell-free DNA (cfDNA) screening or cytogenetic testing. Recent studies showed a possible association with chromosomal anomalies for levels less than 3.5 mm, but extant evidence has limitations.

Objective

To evaluate the association between different nuchal translucency measurements and cytogenetic outcomes on a population level.

Design, setting, and participants

This population-based retrospective cohort study used data from the Better Outcomes Registry & Network, the perinatal registry for Ontario, Canada. All singleton pregnan

SUBMITTER: Bellai-Dussault K 

PROVIDER: S-EPMC10966411 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature