The predictive value of macaque models of preexposure prophylaxis for HIV prevention.

ABSTRACT:

Purpose of review

We review macaque models for preexposure prophylaxis (PrEP) for HIV prevention and highlight their role in advancing currently approved and novel PrEP agents.

Recent findings

The development of the repeat low dose simian HIV (SHIV) challenge models represented a significant advancement in preclinical PrEP modeling that has allowed the investigation of PrEP under conditions that better mimic HIV exposures in humans. These models incorporate relevant drug pharmacology to inform drug correlates of PrEP protection. Models of rectal, vaginal, and penile infection are now available and have been found to predict clinical efficacy of all the currently approved PrEP strategies including daily oral PrEP with the combination of emtricitabine and tenofovir disoproxil

SUBMITTER: Garcia-Lerma JG 

PROVIDER: S-EPMC10966437 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature